Description

4-Amino-2-Iodo-Benzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an amino and an iodo substituent on the benzonitrile core, makes it a valuable precursor for constructing complex heterocycles and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with specific modes of action.
• Material Science Precursor: Used in the research and development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probe Development: Utilized as a starting material for creating fluorescent tags or affinity probes to study biological systems.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of the molecular scaffold.

Basic Information

Product Name	4-Amino-2-Iodo-Benzonitrile
CAS No.	300627-48-9
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	2-Iodo-4-aminobenzonitrile; 4-Amino-2-iodobenzonitrile; 4-Cyano-3-iodoaniline; Benzonitrile, 4-amino-2-iodo-; 3-Iodo-4-cyanobenzenamine
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Iodo-Benzonitrile is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.