Description

Lithium Bis(Dimethylethylsilyl)Amide is a highly reactive, sterically hindered amide base used as a key reagent in advanced organic synthesis. Its primary value lies in its strong basicity and excellent selectivity for deprotonation, enabling the formation of sensitive carbanions under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of complex molecules, organometallic precursors, and novel materials.

Application

• Lithiation Reagent: Selective deprotonation of weakly acidic C-H bonds in complex organic molecules.
• Pharmaceutical Intermediate Synthesis: Key step in the production of active pharmaceutical ingredients (APIs), especially for sterically hindered substrates.
• Polymer Chemistry: Initiation and modification in the synthesis of specialized polymers and elastomers.
• Organometallic Catalyst Preparation: Synthesis of lithium-containing catalysts and precursors for cross-coupling reactions.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and plant growth regulators.
• Materials Science: Precursor for silicon-nitrogen based materials and surface modification agents.

Basic Information

Item	Details
Product Name	Lithium Bis(Dimethylethylsilyl)Amide
CAS No.	300585-49-3
Molecular Formula	C8H22LiNSi2
Molecular Weight	195.37 g/mol
Synonyms	Lithium Bis(tert-butyldimethylsilyl)amide; LiHMDS (Lithium Hexamethyldisilazide) analogue; Lithium Bis[(1,1-dimethylethyl)dimethylsilyl]amide; Lithium N,N-Bis(dimethyl-tert-butylsilyl)amide; (Dimethylethylsilyl)amidolithium; LBTBSA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Lithium Bis(Dimethylethylsilyl)Amide is manufactured under stringent quality systems. Each batch undergoes comprehensive analytical testing to ensure high purity, consistency, and performance for critical synthetic applications. Certificates of Analysis (COA) with detailed specifications for assay, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized. Allow the container to reach room temperature before opening to prevent moisture condensation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Solution Clarity	Clear in specified solvent
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.