Description

4-Bromo-1-(Methylthio)-2-(Trifluoromethyl)-Benzene is a high-purity, multi-functional aromatic building block designed for advanced chemical synthesis. This compound is valued for its unique combination of bromo, methylthio, and trifluoromethyl substituents, which impart significant reactivity and desirable physicochemical properties for creating complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a versatile precursor in the creation of novel herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity conferred by the trifluoromethyl group.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Functional Group Transformation: The methylthio group can be selectively oxidized or displaced, providing a handle for further chemical diversification.
• Fluorine Chemistry Studies: Acts as a model compound in research focused on the influence of the trifluoromethyl group on aromatic system reactivity and biological activity.

Basic Information

Product Name	4-Bromo-1-(Methylthio)-2-(Trifluoromethyl)-Benzene
CAS No.	300356-31-4
Molecular Formula	C8H6BrF3S
Molecular Weight	271.10 g/mol
Synonyms	4-Bromo-1-(methylthio)-2-(trifluoromethyl)benzene; 1-Bromo-4-(methylthio)-3-(trifluoromethyl)benzene; 4-Bromo-α,α,α-trifluoro-2-(methylthio)toluene; 2-(Trifluoromethyl)-4-bromophenyl methyl sulfide; 4-Bromo-2-(trifluoromethyl)thioanisole; 300356-31-4; Benzene, 4-bromo-1-(methylthio)-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Methylthio)-2-(Trifluoromethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The compound is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices for chemicals.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.