Description

Methyl Isocyanoacetate is a versatile and highly reactive organic building block, essential for advanced chemical synthesis. Its unique isocyano and ester functionalities make it a critical reagent for constructing complex heterocycles and peptidomimetics. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of heterocyclic compounds, including imidazoles, oxazoles, and thiazoles, which are core structures in many drug candidates.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators.
• Peptide Mimetics & Ugi Reaction: Serves as a crucial component in multi-component reactions (MCRs), such as the Ugi and Passerini reactions, for rapid generation of chemical diversity libraries.
• Material Science: Building block for specialty polymers and functional materials requiring specific chemical handles.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and bioconjugation reagents for studying biological processes.
• Catalyst Ligand Synthesis: Used to prepare novel ligands for transition metal catalysis.

Basic Information

Product Name	Methyl Isocyanoacetate
CAS No.	39687-95-1
Molecular Formula	C4H5NO2
Molecular Weight	99.09 g/mol
Synonyms	Methyl 2-isocyanoacetate; Isocyanoacetic Acid Methyl Ester; Methyl (Isocyano)acetate; Acetic acid, isocyano-, methyl ester; Methyl isonitroacetate
EINECS	Contact for details

Quality Control

Our Methyl Isocyanoacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.