Description

Desonide 9, 11-Epoxide is a key pharmaceutical intermediate and impurity reference standard. This compound is critical for quality control and research in the development and manufacturing of corticosteroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories, quality assurance departments, and manufacturers specializing in anti-inflammatory and dermatological products.

Application

• Pharmaceutical Impurity Standard: Used as a certified reference material (CRM) for the identification and quantification of related substances in Desonide and similar corticosteroid APIs.
• Process Development & Validation: Serves as a critical intermediate or marker in the research and optimization of synthetic pathways for steroid molecules.
• Analytical Method Development: Employed in developing and validating HPLC, UPLC, or GC methods for purity and stability testing of corticosteroid drugs.
• Regulatory Compliance & Documentation: Essential for preparing regulatory submission documents (e.g., for FDA, EMA) that require characterization of potential degradants and process-related impurities.
• Stability Studies: Used to monitor and understand the degradation profile of Desonide under various stress conditions (e.g., heat, light, humidity).
• Academic & Clinical Research: Supports biochemical and pharmacological studies investigating the structure-activity relationships of corticosteroid compounds.

Basic Information

Product Name	Desonide 9, 11-Epoxide
CAS No.	39672-75-8
Molecular Formula	C24H30O6
Molecular Weight	414.49 g/mol
Synonyms	Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, 9,11-epoxide; 9β,11β-Epoxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione-11β,21-diol; Desonide 9β,11β-Epoxide; 9,11-Epoxy-desonide
EINECS	Contact for details

Quality Control

Our Desonide 9, 11-Epoxide is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for use as a reference standard. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.