Description

Hemoglobin Little Rock CAS NO 39457-37-9 is a specific, well-characterized variant of hemoglobin, a critical oxygen-transporting protein found in red blood cells. This product is essential for biochemical research and diagnostic development, offering a precise model for studying hemoglobinopathies and oxygen-binding kinetics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics sectors for applications ranging from fundamental hematology research to the calibration of analytical instruments.

Application

• Biochemical Research: Used as a reference standard in studies of hemoglobin structure, function, and genetic mutations.
• Diagnostic Development: Serves as a critical component in the formulation and calibration of assays for hemoglobin analysis and blood disorder diagnostics.
• Pharmaceutical R&D: Employed in drug discovery programs targeting sickle cell disease and other hemoglobin-related disorders.
• Academic Studies: A key reagent for university and institutional laboratories focusing on protein chemistry and molecular biology.
• Quality Control: Acts as a control material in the quality assurance processes of clinical laboratories and in-vitro diagnostic (IVD) kit manufacturing.

Basic Information

Product Name	Hemoglobin Little Rock CAS NO 39457-37-9
CAS No.	39457-37-9
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64,500 Da (for α2β2 tetramer)
Synonyms	Hb Little Rock; Hemoglobin Variant Little Rock; Hemoglobin β143(H21)His→Gln; HBB: c.431C>G; High-Oxygen-Affinity Hemoglobin Little Rock; Unstable Hemoglobin Little Rock; Deoxyhemoglobin Little Rock; Oxyhemoglobin Little Rock
EINECS	Contact for details

Quality Control

Our Hemoglobin Little Rock is produced and handled under stringent conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is subjected to a comprehensive suite of analytical tests, including purity assessment by HPLC, spectral analysis, and functional activity checks. A Certificate of Analysis (COA) detailing identity, purity, and specific biological activity is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	≤ 5%
Oxygen Affinity (p50)	Characterized, lot-specific
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.