Description

Hemoglobin S, Carbamylated is a chemically modified derivative of sickle cell hemoglobin (HbS) where specific amino groups have been reacted with cyanate. This product is a critical biochemical reagent for advanced research and diagnostic development, offering a stable and well-characterized reference material. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in hematology studies, sickle cell disease research, and the calibration of analytical instruments.

Application

• Biochemical Research: Used as a key reference standard in studies investigating the structure, function, and polymerization kinetics of sickle cell hemoglobin.
• Diagnostic Development: Serves as a critical calibrant and control material in the development and validation of diagnostic assays for sickle cell disease and related hemoglobinopathies.
• Pharmaceutical R&D: Employed in drug discovery programs targeting sickle cell disease, particularly for screening compounds that inhibit HbS polymerization.
• Clinical Laboratory Standards: Used to establish quality control protocols and ensure accuracy in clinical laboratories performing hemoglobin electrophoresis or chromatography.
• Educational & Training Kits: Incorporated into advanced educational kits for medical and biochemistry training to demonstrate protein modification and disease mechanisms.

Basic Information

Product Name	Hemoglobin S, Carbamylated
CAS No.	39454-80-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Carbamylated Hemoglobin S; CarbHb S; Sickle Cell Hemoglobin, Carbamylated; HbS-Carb; Cyanate-modified Hemoglobin S; Modified Sickle Hemoglobin; Carbamylated HbS; Hb SCarb
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and diagnostic use. Each batch is characterized for identity, purity, and degree of carbamylation using advanced analytical techniques. Certificates of Analysis (COA) detailing specific test results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR / HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Degree of Carbamylation	Specified per batch
Solubility	Soluble in aqueous buffers
Residual Moisture (KF)	< 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.