Description

Quinolinic Acid Synthetase is a key enzyme involved in the biosynthesis of quinolinic acid, a critical intermediate in the *de novo* NAD+ synthesis pathway. This compound is essential for research and development in neurochemistry and metabolic studies, where understanding NAD+ metabolism is crucial. It is primarily utilized by biochemical researchers, pharmaceutical developers, and diagnostic manufacturers focusing on neurodegenerative disorders, metabolic diseases, and enzyme kinetics.

Application

• Biochemical Research: Used as a standard or reagent in studies investigating the kynurenine pathway and NAD+ biosynthesis.
• Pharmaceutical Development: Serves as a target enzyme for drug discovery programs aimed at modulating neuroactive metabolite levels, particularly in conditions like Huntington's disease, Alzheimer's, and depression.
• Diagnostic Kit Manufacturing: Employed in the production of assay kits for measuring enzyme activity or metabolite levels in clinical and research samples.
• Enzymology Studies: Essential for kinetic analysis, inhibition studies, and characterizing the structure-function relationship of this specific synthetase.
• Academic Research: Utilized in university and institutional labs for fundamental research on cellular metabolism and neuroinflammation.

Basic Information

Product Name	Quinolinic Acid Synthetase
CAS No.	39434-08-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Quinolinate Synthase; 2,3-Dihydroxybenzoate Serine-Lysine Ligase (FAD); QS; EC 2.5.1.72; 3-Hydroxyanthranilate 3,4-dioxygenase (decyclizing, quinolinoyl-forming); 3HAO; 3-Hydroxyanthranilate Oxidase; 3-Hydroxyanthranilic Acid Oxygenase
EINECS	Contact for details

Quality Control

Our Quinolinic Acid Synthetase is produced and tested under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and functional integrity. A comprehensive Certificate of Analysis (COA) detailing purity, activity units, and stability data is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under controlled, dry conditions to maintain activity. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Purity (SDS-PAGE)	≥ 90%
Specific Activity	Defined units/mg protein
Protein Concentration	Defined mg/mL
Buffer Composition	Defined stabilizer buffer
Endotoxin Level	< 1.0 EU/μg (if applicable)
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.