Description

Angiotensin II, Leu(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at the 8th position with a leucine residue. This modification is critical for research into the structure-activity relationships of the renin-angiotensin system (RAS) and for developing selective receptor ligands. It serves as an essential biochemical tool for pharmaceutical R&D, particularly in cardiovascular and renal disease research. High-purity grades are fundamental for ensuring reliable and reproducible experimental data in both academic and industrial settings.

Application

• Biochemical Research: Fundamental tool for studying the renin-angiotensin system (RAS), receptor binding kinetics, and signal transduction pathways.
• Pharmaceutical Development: Used as a reference standard and a key intermediate in the discovery and development of novel antihypertensive drugs and AT1/AT2 receptor modulators.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (e.g., ELISA) to measure angiotensin peptides or related antibodies.
• Cell Culture & Physiology Studies: Applied in cellular models to investigate the effects of angiotensin receptor stimulation on vascular smooth muscle contraction, aldosterone secretion, and cardiac function.
• Enzyme Substrate/Inhibitor Studies: Acts as a substrate for angiotensin-converting enzyme (ACE) and other proteases in enzymatic activity assays.
• Peptide Chemistry & Conjugation: Serves as a building block or target molecule for peptide synthesis, labeling (e.g., fluorescent, radioactive), and bioconjugation projects.

Basic Information

Product Name	Angiotensin II, Leu(8)-
CAS No.	39409-20-6
Molecular Formula	C₅₀H₇₁N₁₃O₁₂
Molecular Weight	1030.2 g/mol
Synonyms	Leu(8)-Angiotensin II; [Leu8]-Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Leu; L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-leucine; Angiotensin II (5-L-Isoleucine, 8-L-leucine); H-Asp-Arg-Val-Tyr-Ile-His-Pro-Leu-OH; Saralasin Acetate related peptide A; ATII Leu8
EINECS	Contact for details

Quality Control

Every batch of Angiotensin II, Leu(8)- is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including multiple orthogonal methods, to ensure identity, purity, and consistency that meet the stringent requirements of research and development. Certificates of Analysis (COA) providing detailed chromatographic and spectroscopic data are available for every lot and supplied upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.