Description

Inter-α-Inhibitor is a complex, naturally occurring glycoprotein complex that plays a critical role in modulating inflammatory and proteolytic processes. Its primary value lies in its potent inhibitory activity against serine proteases, making it a key regulator in physiological and pathological cascades. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and diagnostic industries, particularly for studies in inflammation, sepsis, cancer metastasis, and tissue remodeling.

Application

• Biomedical Research: Used as a critical reagent in studying inflammatory pathways, protease networks, and disease mechanisms.
• Therapeutic Development: Serves as a reference standard or starting material for developing novel anti-inflammatory and anti-metastatic biologics.
• Diagnostic Assays: Employed in the calibration and development of immunoassays to measure Inter-α-Inhibitor levels in clinical samples.
• Cell Culture & Tissue Engineering: Utilized in in vitro studies to understand its role in cell migration, extracellular matrix stability, and stem cell biology.
• Protease Inhibition Studies: Acts as a broad-spectrum serine protease inhibitor in biochemical and enzymatic research.
• Standard for Quality Control: Used as a purity standard in the production and QC of related biopharmaceutical products.

Basic Information

Product Name	Inter-α-Inhibitor
CAS No.	39346-44-6
Molecular Formula	Contact for details
Molecular Weight	~220 kDa (Complex)
Synonyms	Inter-α-inhibitor
IαI
ITI
Inter Alpha Trypsin Inhibitor
Plasma-Derived Inter-α-Inhibitor
Serum-Derived Inter-α-Inhibitor
Pre-α-inhibitor (related family)
EINECS	Contact for details

Quality Control

Our Inter-α-Inhibitor is produced and tested under stringent conditions to ensure high biological activity and purity. Each batch is characterized using advanced analytical techniques including SDS-PAGE, Western Blot, and functional activity assays. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, activity, and endotoxin levels, ensuring it meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, aliquots may be stored at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE/Western Blot)	Complies
Purity (HPLC/SEC)	≥ 90%
Protein Content (UV Absorbance)	Specified on COA
Biological Activity (Protease Inhibition)	Specified on COA
Endotoxin Level (LAL Test)	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.