Description

Triphenylphosphine Resin is a functionalized polymer support where triphenylphosphine ligands are covalently bound to a cross-linked polystyrene matrix. This product is a versatile and reusable reagent that combines the catalytic and stoichiometric utility of triphenylphosphine with the practical advantages of solid-phase synthesis. It is essential for laboratories and facilities engaged in high-value organic synthesis, particularly where purification and catalyst recovery are critical. Key industries that utilize this material include pharmaceutical R&D, fine chemical production, and academic research for applications such as Mitsunobu reactions, Staudinger reductions, and as a ligand for transition metal catalysts.

Application

• Solid-Phase Organic Synthesis (SPOS): Acts as a polymer-supported reagent for Mitsunobu reactions, Wittig olefinations, and Staudinger-type reductions, enabling simplified work-up and purification.
• Catalyst and Ligand Support: Serves as a heterogeneous ligand for transition metal catalysts (e.g., palladium) in cross-coupling reactions like Suzuki and Heck reactions, facilitating catalyst recovery and recycling.
• Pharmaceutical Intermediate Production: Used in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) where high purity and process efficiency are paramount.
• Peptide Synthesis: Employed in the activation of carboxylic acids for amide bond formation on solid support.
• Scavenging Applications: Useful for removing excess reagents, such as acyl chlorides or isocyanates, from reaction mixtures in combinatorial chemistry.
• Academic and Process Research: A valuable tool for developing new synthetic methodologies and optimizing chemical processes in a research setting.

Basic Information

Product Name	Triphenylphosphine Resin
CAS No.	39319-11-4
Molecular Formula	(C20H15P)n (Representative monomer unit on polymer support)
Molecular Weight	~262.3 (monomeric unit) - Polymer MW varies with loading and cross-linking
Synonyms	Polymer-supported triphenylphosphine; Polystyrene-triphenylphosphine; PPh3 Resin; Triphenylphosphine polystyrene resin; Triphenylphosphine functionalized resin; Merrifield's resin triphenylphosphine derivative; Phosphine resin; 2-Diphenylphosphinopolystyrene
EINECS	Contact for details

Quality Control

Our Triphenylphosphine Resin is manufactured under strict quality protocols. Each batch undergoes rigorous testing to ensure consistent performance, including analysis of phosphorous loading capacity, bead size distribution, and functional integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as phosphorous content, swelling capacity in common solvents, and residual chloride levels. Our quality system is designed to support cGMP and ISO standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its polymeric nature and sensitivity to oxidation, it is recommended to store the resin under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original packaging has been opened. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow beads
Loading Capacity	0.5 - 3.0 mmol/g (Typical)
Mesh Size	100-200 mesh (or as specified)
Cross-linking	1-2% DVB (Typical)
Identification (IR)	Conforms to structure
Moisture Content	< 1.0 %
Swelling Volume	Reported (DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.