Description

Imp. A (Ep): (Rs)-2-Chloro-n-(2-Methylphenyl)-Propanamide is a high-purity chiral intermediate of significant importance in the synthesis of advanced pharmaceutical compounds. Its defined stereochemistry and structural features make it a critical building block for creating active pharmaceutical ingredients (APIs) with specific therapeutic profiles. This compound is essential for research and development laboratories, as well as production facilities, operating within the fine chemical and pharmaceutical sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly in developing analgesics and other central nervous system (CNS) agents.
• Active Pharmaceutical Ingredient (API) Impurity Standard: Serves as a certified reference material (Imp. A) for analytical method development, validation, and quality control testing of APIs, ensuring compliance with pharmacopeial standards like the European Pharmacopoeia (EP).
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct molecules with high enantiomeric purity, which is crucial for modern drug discovery.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and novel compound libraries.
• Process Chemistry: Used in scaling up and optimizing manufacturing routes for target pharmaceutical compounds.

Basic Information

Product Name	Imp. A (Ep): (Rs)-2-Chloro-n-(2-Methylphenyl)-Propanamide
CAS No.	39084-88-3
Molecular Formula	C10H12ClNO
Molecular Weight	197.66 g/mol
Synonyms	(R,S)-2-Chloro-N-(2-methylphenyl)propanamide; 2-Chloro-N-(2-methylphenyl)propanamide; N-(2-Methylphenyl)-2-chloropropanamide; Propanamide, 2-chloro-N-(2-methylphenyl)-; Impurity A of EP Monograph; (RS)-2-Chloro-N-(o-tolyl)propanamide
EINECS	Contact for details

Quality Control

Our Imp. A (Ep): (Rs)-2-Chloro-n-(2-Methylphenyl)-Propanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, chiral analysis, and spectroscopic identification, to ensure it meets the stringent specifications required for use as a pharmaceutical reference standard. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Optical Purity (Chiral HPLC)	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.