Description

Cobamamide 5'-Phosphate is a biologically active coenzyme form of vitamin B12, essential for critical metabolic functions. This high-purity compound is vital for applications requiring a direct and potent source of this vitamin cofactor. It is primarily utilized by the pharmaceutical, nutraceutical, and advanced research sectors for formulation and biochemical studies.

Application

• Pharmaceutical Formulations: As an active pharmaceutical ingredient (API) in injectable and oral medications for treating vitamin B12 deficiency and related neurological disorders.
• Nutraceutical & Dietary Supplements: A key ingredient in high-efficacy supplements, offering superior bioavailability compared to cyanocobalamin.
• Cell Culture & Fermentation Media: Used as a growth factor in mammalian cell culture and microbial fermentation processes to support cell proliferation and product yield.
• Biochemical Research: Essential for enzymatic studies, metabolic pathway analysis, and as a standard in analytical laboratories.
• Veterinary Medicine: Incorporated into animal health products for livestock and companion animals to ensure proper metabolic function.
• Cosmeceuticals: Formulated into advanced skincare products for its purported role in cell regeneration and skin vitality.

Basic Information

Product Name	Cobamamide 5'-Phosphate
CAS No.	39044-48-9
Molecular Formula	C72H100CoN18O17P
Molecular Weight	1579.6 g/mol
Synonyms	Adenosylcobalamin 5'-Phosphate; Coenzyme B12 Phosphate; Dibencozide Phosphate; AdoCbl-P; Cobamamide Phosphate; Vitamin B12 Coenzyme Phosphate; 5'-Deoxyadenosylcobalamin 5'-Phosphate; Coα-[α-(5,6-Dimethylbenzimidazolyl)]-Coβ-(5'-deoxy-5'-adenosyl)cobamide 5'-Phosphate
EINECS	Contact for details

Quality Control

Our Cobamamide 5'-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and UV-Vis spectroscopy, and tests for related substances and residual solvents. Certificates of Analysis (COA) confirming compliance with in-house specifications are available upon request. We support development toward pharmacopeial standards (USP/EP) for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen) after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	Dark red crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Optical Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.