Description

Phenyl-α-L-Iduronide is a specialized monosaccharide derivative, specifically a phenyl glycoside of α-L-iduronic acid. This compound serves as a crucial biochemical tool and synthetic intermediate for research and development in enzymology and carbohydrate chemistry. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions focused on lysosomal storage disorders, glycosaminoglycan metabolism, and enzyme substrate development.

Application

• Enzyme Substrate & Assay Development: Acts as a specific chromogenic or fluorogenic substrate for the assay of α-L-iduronidase activity, critical for research into Mucopolysaccharidosis I (Hurler, Scheie, and Hurler-Scheie syndromes).
• Biochemical Research: Used in studies of lysosomal enzyme kinetics, inhibitor screening, and understanding the catabolic pathways of dermatan sulfate and heparan sulfate.
• Diagnostic Reagent Manufacturing: Serves as a key raw material in the production of in vitro diagnostic (IVD) kits for the detection of enzyme deficiencies.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex molecules for potential therapeutic applications targeting glycosidase-related diseases.
• Quality Control Reference Standard: Used as a certified reference material (CRM) in pharmaceutical QC labs to validate assay methods for enzyme replacement therapies.
• Academic & Institutional Research: Supports fundamental research in glycobiology, enzymology, and metabolic disease modeling.

Basic Information

Product Name	Phenyl-α-L-Iduronide
CAS No.	39031-71-5
Molecular Formula	C12H14O6
Molecular Weight	254.24 g/mol
Synonyms	Phenyl α-L-idopyranosiduronic acid; Phenyl α-L-iduronide; 4-O-α-L-Idopyranosyluronic acid phenyl; α-L-Idopyranosiduronic acid, phenyl-; Phenyl-α-L-idopyranosiduronate; α-L-Iduronidase substrate; Iduronide, Phenyl-α-L-
EINECS	Contact for details

Quality Control

Our Phenyl-α-L-Iduronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.