Description

Icr 191-Oh CAS NO 38915-18-3 is a specialized chemical compound, specifically a derivative of the acridine dye ICR 191, which is a well-known frameshift mutagen. This product is a key intermediate or reference standard in advanced research and development. It is critical for scientists and manufacturers requiring high-purity, well-characterized compounds for precise experimental work. This material is primarily utilized in the fields of molecular biology, genetic toxicology, and pharmaceutical research.

Application

• Genetic Toxicology Research: Used as a reference standard and active agent in Ames tests and other mutagenicity assays to study frameshift mutations.
• Molecular Biology Studies: Serves as a crucial tool compound for investigating DNA intercalation mechanisms and mutagenic pathways.
• Pharmaceutical Development: Employed in safety screening and genotoxicity testing of new drug candidates during preclinical stages.
• Academic & Institutional Research: Essential for university and government labs focused on genetics, carcinogenesis, and DNA repair processes.
• Chemical Intermediate: Acts as a building block for the synthesis of more complex acridine derivatives for specialized applications.
• Quality Control Standards: Used by manufacturers and testing laboratories to calibrate equipment and validate assay protocols for mutagen detection.

Basic Information

Product Name	Icr 191-Oh
CAS No.	38915-18-3
Molecular Formula	C22H21N3O3
Molecular Weight	375.42 g/mol
Synonyms	6-Chloro-9-[3-(2-hydroxyethyl)aminopropylamino]-2-methoxyacridine; ICR 191-OH; ICR-191 Hydroxy Derivative; Acridine Orange derivative; Frameshift mutagen derivative; 2-Methoxy-6-chloro-9-(3-(2-hydroxyethyl)aminopropylamino)acridine; 6-Chloro-2-methoxy-9-((3-((2-hydroxyethyl)amino)propyl)amino)acridine
EINECS	Contact for details

Quality Control

Every batch of Icr 191-Oh is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency suitable for research applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay purity and impurity profiles. Our quality systems are designed to meet the exacting standards required for reference materials and biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Water Content	≤ 2.0% (KF)
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.