Description

1,N6-Etheno Nad is a chemically modified nucleoside analog of interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a model adduct for studying nucleic acid damage, repair mechanisms, and the biological effects of etheno-bridged lesions. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncological research, mutagenesis studies, and the development of novel diagnostic tools.

Application

• Biomarker Research: Used as a standard or reference compound in the study of DNA adducts formed from lipid peroxidation or exposure to certain carcinogens.
• Mechanistic Studies: Essential for investigating the enzymatic pathways involved in DNA repair, particularly base excision repair (BER).
• Analytical Standard: Serves as a high-purity calibrant in liquid chromatography-mass spectrometry (LC-MS) and other analytical methods for quantifying DNA damage.
• Pharmaceutical Development: Employed in early-stage research for evaluating the genotoxic potential of new chemical entities and understanding mutation spectra.
• Biochemical Tool: Incorporated into oligonucleotides to probe the structural and functional consequences of specific DNA lesions on polymerase fidelity and protein binding.

Basic Information

Product Name	1,N6-Etheno Nad
CAS No.	38806-38-1
Molecular Formula	C₁₂H₁₄N₆O₅
Molecular Weight	322.28 g/mol
Synonyms	1,N6-Ethenoadenosine; 1,N6-Etheno-adenosine; 1,N6-Ethenoadenosine; 1,N6-ε-Adenosine; ε-Ado; 3-β-D-Ribofuranosylimidazo[2,1-i]purine; Adenosine, 1,N6-etheno-
EINECS	Contact for details

Quality Control

Our 1,N6-Etheno Nad is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.