Description

4-Bromo-1-Butyne is a versatile alkyne building block containing both a reactive terminal alkyne and a bromine functional group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) via Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in creating novel fungicides, herbicides, and plant growth regulators that require alkyne-based scaffolds.
• Material Science: Serves as a monomer or cross-linker in the production of specialty polymers, conductive materials, and metal-organic frameworks (MOFs).
• Chemical Research: Essential reagent in organic synthesis for constructing carbon-carbon bonds and introducing the alkyne moiety into target molecules.
• Ligand and Catalyst Development: Used to synthesize novel phosphine or nitrogen-based ligands for asymmetric catalysis.
• Fluorescent Probe Synthesis: Acts as a precursor for developing fluorescent dyes and molecular probes used in bioimaging and diagnostics.

Basic Information

Product Name	4-Bromo-1-Butyne
CAS No.	38771-21-0
Molecular Formula	C₄H₅Br
Molecular Weight	132.99 g/mol
Synonyms	1-Bromo-3-butyne; 3-Butyn-1-yl bromide; But-3-yn-1-yl bromide; 4-Bromobut-1-yne; 3-Butynyl bromide; (3-Butynyl) bromide; Bromobutylene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Butyne is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, ensure containers are kept tightly sealed to prevent moisture ingress and volatility.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.