Description

Genistein 7-β-D-Glucuronide is a major phase II metabolite of the soy isoflavone genistein, formed via glucuronidation. This compound is of significant interest for its role in bioavailability studies and as a critical reference standard for analytical research. It is primarily required by pharmaceutical R&D laboratories, nutraceutical manufacturers, and academic institutions focused on pharmacokinetics, metabolism, and biomarker analysis.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification of genistein metabolites in biological matrices via HPLC, LC-MS, or LC-MS/MS.
• Pharmacokinetic & Metabolism Studies: Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of genistein and related isoflavones in preclinical and clinical research.
• Biomarker Development: Serves as a precise calibrator for developing assays to measure isoflavone exposure and metabolic status in human plasma, serum, or urine.
• Nutraceutical & Clinical Research: Employed in studies evaluating the bioavailability, efficacy, and safety of soy-based supplements and functional foods.
• Enzyme Activity Assays: Used as a specific substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in drug metabolism.

Basic Information

Product Name	Genistein 7-β-D-Glucuronide
CAS No.	38482-81-4
Molecular Formula	C21H18O11
Molecular Weight	446.36 g/mol
Synonyms	Genistein 7-O-β-D-Glucuronide; Genistein 7-Glucuronide; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 7-β-D-Glucopyranosiduronic Acid; 7-Glucuronyl Genistein; Genistein-7-glucuronide; NSC 113492; Genistein 7-O-glucuronide
EINECS	Contact for details

Quality Control

Our Genistein 7-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.