Description

2-Chloro-1,3-Difluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active ingredients, specialty chemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorophenyl or chlorophenyl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated aromatic compounds for electronic display and lighting applications.
• Polymer & Resin Modification: Acts as a monomer or modifier to introduce fluorine and chlorine atoms into polymer chains, altering properties like chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, multi-substituted benzene derivatives.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized halogenated dyes and pigments.

Basic Information

Product Name	2-Chloro-1,3-Difluorobenzene
CAS No.	38361-37-4
Molecular Formula	C6H3ClF2
Molecular Weight	148.54 g/mol
Synonyms	1-Chloro-2,4-Difluorobenzene; 2,4-Difluorochlorobenzene; Benzene, 2-chloro-1,3-difluoro-; 2-Chloro-1,3-difluorobenzol; 2-Chloro-m-difluorobenzene; 2,4-Difluoro-1-chlorobenzene; 1-Chloro-2,4-difluorobenzol; 2,4-DFCB
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,3-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	~1.40 g/mL
Refractive Index (n20D)	~1.48

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.