Description

Lithium Tetramethylpiperidide is a highly reactive, non-nucleophilic strong base, widely recognized for its utility in deprotonation reactions. This compound matters for its ability to generate reactive intermediates under mild conditions, offering chemists a powerful tool for constructing complex molecules. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring precise and selective metallation.

Application

• As a strong, non-nucleophilic base for the deprotonation of weak carbon acids in organic synthesis.
• Key reagent in the preparation of organolithium compounds and other sensitive carbanions.
• Used in polymerization initiator systems and catalyst preparation for advanced materials.
• Facilitates directed ortho-metalation (DoM) reactions in medicinal chemistry for drug discovery.
• Employed in the synthesis of fine chemicals and complex natural product analogs.
• Useful in ligand exchange reactions and the preparation of specialty organometallic reagents.

Basic Information

Product Name	Lithium Tetramethylpiperidide
CAS No.	38227-87-1
Molecular Formula	C9H18LiN
Molecular Weight	147.18 g/mol
Synonyms	LiTMP; Lithium 2,2,6,6-Tetramethylpiperidide; 1-Lithio-2,2,6,6-tetramethylpiperidine; 2,2,6,6-Tetramethylpiperidin-1-ium-1-ide, lithium salt; TMPLi; Lithium 1-(2,2,6,6-tetramethylpiperidinyl); Lithium 2,2,6,6-tetramethylpiperidin-1-ide
EINECS	Contact for details

Quality Control

Our Lithium Tetramethylpiperidide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. The product undergoes rigorous analytical testing, including titration and spectroscopic methods, to confirm identity and purity. Certificates of Analysis (COA) detailing all quality parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its hygroscopic and pyrophoric nature, the material must be handled and stored with appropriate precautions to exclude moisture and air. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or solution
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0%
Solvent (if supplied as solution)	Specified (e.g., THF, Hexane)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.