Description

Lithium Isopropylamide is a powerful, non-nucleophilic base widely used in organic synthesis. Its high basicity and low nucleophilicity make it an essential reagent for the generation of kinetic enolates and the deprotonation of weakly acidic substrates. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and fine chemical industries, where precise control over reaction pathways is critical. The product is supplied as a solution, typically in hydrocarbon solvents, to ensure stability and ease of handling.

Application

• As a strong base for the generation of kinetic enolates in aldol and alkylation reactions.
• Deprotonation agent in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• Key reagent in metallation reactions for the preparation of organolithium compounds.
• Facilitator in ring-opening and anionic polymerization processes for specialty polymers.
• Used in the synthesis of natural products and complex organic molecules requiring regioselective deprotonation.
• Employed in methodological development and scale-up processes within R&D and pilot plant operations.

Basic Information

Product Name	Lithium Isopropylamide
CAS No.	38225-32-0
Molecular Formula	C3H8LiN
Molecular Weight	65.04 g/mol
Synonyms	LDA (Lithium Diisopropylamide); Lithium Diisopropylamide; Diisopropylaminolithium; N-Lithiodiisopropylamine; N-(Propan-2-yl)propan-2-aminolithium; 2-Propanamine, N-(1-methylethyl)-, lithium salt; Lithium diisopropylamide solution; Lithium N,N-diisopropylamide
EINECS	Contact for details

Quality Control

Our Lithium Isopropylamide solutions undergo rigorous quality testing to ensure consistency, purity, and performance for critical synthetic applications. Each batch is analyzed to confirm concentration, base strength, and the absence of deleterious impurities. Certificates of Analysis (COA) detailing assay, solvent content, and other relevant parameters are available upon request. Our quality management system supports compliance with cGMP and other relevant industry standards for advanced synthetic reagents.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed and away from moisture. Recommended storage temperature is 2-8°C for extended stability. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to slightly yellow solution
Concentration	Typically 2.0 M in THF/Hexanes or other specified solvent
Assay (Titration)	≥ 95.0% (of stated concentration)
Identification (IR)	Conforms to reference
Solvent Content (GC)	Balance
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.