Description

4-trans-Hydroxyglipizide is a key pharmaceutical intermediate and metabolite of the antidiabetic drug glipizide. This compound is of significant importance for research and development in the synthesis of new therapeutic agents and for conducting detailed metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) who require high-purity building blocks.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of sulfonylurea-based antidiabetic drugs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the pharmacokinetics and metabolism of glipizide.
• Research Chemical: Employed in academic and industrial research for investigating structure-activity relationships (SAR) and developing new therapeutic compounds.
• Quality Control: Serves as a reference material in the quality assurance and impurity profiling of glipizide API and finished dosage forms.

Basic Information

Product Name	4-trans-Hydroxyglipizide
CAS No.	38207-36-2
Molecular Formula	C21H27N5O4S
Molecular Weight	445.54 g/mol
Synonyms	4-trans-Hydroxy Glipizide; 4-Hydroxyglipizide; Glipizide Metabolite; 1-Cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea, 4-Hydroxy Derivative; 4-OH Glipizide; trans-4-Hydroxyglipizide; N-[4-[2-[[[[(trans-4-Hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]ethyl]phenyl]-5-methyl-2-pyrazinecarboxamide
EINECS	Contact for details

Quality Control

Our 4-trans-Hydroxyglipizide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.