Description

Z-Lys(Z)-Gly-Oh is a protected dipeptide building block, specifically a derivative of lysine and glycine. This compound is essential for the controlled synthesis of complex peptides and peptidomimetics in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry, bioconjugation, and proteomics for creating novel therapeutic agents and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of longer peptide chains, particularly where orthogonal protection of the lysine side chain is required.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals, including hormone analogs, enzyme inhibitors, and targeted drug delivery systems.
• Bioconjugation and Labeling: Serves as a spacer or functional handle for attaching fluorophores, biotin, or other moieties to peptides and proteins for diagnostic and imaging applications.
• Proteomics Research: Employed in the synthesis of substrate analogs, activity-based probes, and isotopically labeled internal standards for mass spectrometry.
• Custom Peptide Service: A critical raw material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis services.

Basic Information

Product Name	Z-Lys(Z)-Gly-Oh
CAS No.	37941-54-1
Molecular Formula	C₂₂H₂₅N₃O₆
Molecular Weight	427.45 g/mol
Synonyms	N2-[(Benzyloxy)carbonyl]-N6-[(benzyloxy)carbonyl]-L-lysylglycine; Nα-Cbz-Nε-Cbz-L-lysyl-glycine; Z-Lys(Z)-Gly-OH; Cbz-Lys(Cbz)-Gly-OH; Nα-Carbobenzoxy-Nε-carbobenzoxy-L-lysylglycine; (2S)-6-{[(Benzyloxy)carbonyl]amino}-2-{[(benzyloxy)carbonyl]amino}hexanoylglycine; Nα,Nε-Bis-Cbz-L-lysylglycine
EINECS	Contact for details

Quality Control

Our Z-Lys(Z)-Gly-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for peptide building blocks, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.