Description

n-(Deoxyguanosin-8-Yl)Acetylaminofluorene is a high-purity, well-characterized DNA adduct standard critical for research in chemical carcinogenesis and molecular toxicology. This compound serves as an essential reference material for the accurate detection and quantification of DNA damage caused by exposure to polycyclic aromatic hydrocarbons and aromatic amines. It is primarily utilized by research scientists and quality control laboratories in pharmaceutical development, environmental safety testing, and academic research focused on mutagenesis and DNA repair mechanisms.

Application

• Biomarker Standard in Toxicological Studies: Used as a quantitative standard in HPLC-MS/MS or 32P-postlabeling assays to measure DNA adduct formation in vitro and in vivo.
• Metabolic Pathway Research: Essential for studying the metabolic activation of procarcinogens like 2-acetylaminofluorene and the resulting DNA binding profiles.
• Method Development and Validation: Serves as a critical calibrant for developing and validating sensitive analytical methods for DNA adductomics.
• Quality Control in Genotoxicity Testing: Employed as a reference standard in laboratories performing genotoxicity assays to ensure accuracy and reproducibility.
• Educational and Reference Material: Used in advanced university courses and research institutions for teaching principles of molecular toxicology.
• Standards for Regulatory Submissions: Supports preclinical and environmental health risk assessments by providing definitive analytical standards for regulatory documentation.

Basic Information

Product Name	n-(Deoxyguanosin-8-Yl)Acetylaminofluorene
CAS No.	37819-60-6
Molecular Formula	C26H25N7O5
Molecular Weight	515.52 g/mol
Synonyms	N-(Deoxyguanosin-8-yl)-2-acetylaminofluorene; 8-(N-2-Fluorenylacetamido)deoxyguanosine; dG-C8-AAF; AAF-dG Adduct; 2-AAF-DNA Adduct; N-(Deoxyguanosin-8-yl)-AAF; C8-dG-AAF; Guanine-AAF Adduct
EINECS	Contact for details

Quality Control

Every batch of n-(Deoxyguanosin-8-Yl)Acetylaminofluorene is produced and analyzed under strict quality protocols to ensure identity, purity, and stability. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for HPLC purity, spectroscopic identification (UV, NMR), and moisture content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic nature, the container must be allowed to reach room temperature before opening to prevent condensation and moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms to reference spectrum
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.