Description

2-Chloro-6-Fluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive carboxylic acid group and a halogenated aromatic ring, enabling precise molecular construction. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs) with fluorinated motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic display and lighting materials.
• Organic Synthesis Reagent: Employed in coupling reactions (e.g., Suzuki, Heck) and as a starting material for generating more complex fluorinated compounds via the acetic acid moiety.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new synthetic pathways and creating novel fluorinated molecular libraries.

Basic Information

Product Name	2-Chloro-6-Fluorophenylacetic Acid
CAS No.	37777-76-7
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	(2-Chloro-6-fluorophenyl)acetic Acid; 2-Chloro-6-fluoro-α-toluic Acid; 2-Chloro-6-fluorobenzeneacetic Acid; NSC 406908; o-Chloro-o'-fluorophenylacetic Acid; 2-Fluoro-6-chlorophenylacetic Acid; α-(2-Chloro-6-fluorophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluorophenylacetic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.