Description

4,4-Difluoro-But-2-Enoic Acid is a versatile fluorinated building block characterized by its difluoroalkene and carboxylic acid functionalities. This compound is highly valued in advanced organic synthesis for its ability to introduce fluorine atoms and serve as a reactive handle for further derivatization. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, leveraging fluorine's ability to enhance bioavailability and metabolic stability.
• Material Science: Serves as a monomer or precursor for specialty polymers and advanced materials with tailored surface properties.
• Fluorine Chemistry Research: An essential reagent for studying nucleophilic addition and cycloaddition reactions involving fluorinated olefins.
• Ligand and Catalyst Development: Employed in the preparation of fluorinated ligands for metal complexes used in catalysis.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for complex, high-value fluorinated molecules.

Basic Information

Product Name	4,4-Difluoro-But-2-Enoic Acid
CAS No.	37759-73-2
Molecular Formula	C4H4F2O2
Molecular Weight	122.07 g/mol
Synonyms	4,4-Difluorobut-2-enoic Acid; (E)-4,4-Difluorobut-2-enoic Acid; 4,4-Difluoro-2-butenoic Acid; 2-Butenoic acid, 4,4-difluoro-; trans-4,4-Difluorocrotonic Acid; 4,4-Difluorocrotonic Acid; DFBA
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-But-2-Enoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all commercial quantities. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.