Description

D-Proline, 1-Acetyl-4-Hydroxy-, (4R)- (9Ci) CAS NO 37712-75-7 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 4-position. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the creation of complex molecules with precise stereochemical control. It is essential for research and development in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used in the design and development of peptide analogs and mimetics to enhance stability and bioavailability.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in catalytic and stoichiometric asymmetric reactions.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for proline-specific enzymes.
• Agrochemical Development: Potential intermediate for creating chiral herbicides, fungicides, or plant growth regulators.
• Material Science: Can be utilized in the synthesis of specialty polymers or functionalized surfaces requiring specific stereochemistry.

Basic Information

Product Name	D-Proline, 1-Acetyl-4-Hydroxy-, (4R)- (9Ci)
CAS No.	37712-75-7
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(4R)-1-Acetyl-4-hydroxy-D-proline; (R)-1-Acetyl-4-hydroxyproline; 1-Acetyl-4-hydroxy-D-proline; 4-Hydroxy-1-acetyl-D-proline; D-1-Acetyl-4-hydroxyproline; (4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid; 37712-75-7; AC1L1WVL
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Acetyl-4-Hydroxy-, (4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.