Description

Aprindine is a class Ic antiarrhythmic agent, a sodium channel blocker used to treat and prevent various cardiac arrhythmias. Its primary value lies in its ability to stabilize the cardiac membrane and reduce the excitability of heart muscle cells. This pharmaceutical intermediate is essential for manufacturers in the pharmaceutical and fine chemical sectors developing cardiovascular medications.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in antiarrhythmic drug formulations.
• Cardiovascular Research: A critical reference standard and tool compound in preclinical and clinical studies of cardiac electrophysiology.
• Chemical Synthesis: Serves as a key intermediate for the synthesis of more complex antiarrhythmic agents and related chemical entities.
• Generic Drug Manufacturing: Essential for companies producing generic versions of established antiarrhythmic medications containing Aprindine.
• Metabolite Studies: Used in the development and validation of analytical methods for drug metabolism and pharmacokinetic (DMPK) research.

Basic Information

Product Name	Aprindine
CAS No.	37640-71-4
Molecular Formula	C22H30N2
Molecular Weight	322.49 g/mol
Synonyms	N-(3-(Diethylamino)propyl)-N-phenyl-1-indanamine; N-[3-(Diethylamino)propyl]-N-phenyl-1H-inden-1-amine; Fibocil; Amidonal; Fiboran; AC-1802; Aprindine Hydrochloride (salt form); Fiboran
EINECS	253-589-5

Quality Control

Our Aprindine CAS NO 37640-71-4 is manufactured under strict quality systems. We provide material that meets high-purity standards suitable for pharmaceutical R&D and manufacturing. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring traceability and compliance with relevant guidelines. Specifications can be aligned with pharmaceutical grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.