Description

1,1,1-Trifluoro-n-(4-Nitrophenyl)-n-[(Trifluoromethyl)Sulfonyl]Methanesulfonamide is a specialized fluorinated sulfonamide derivative of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethylsulfonyl (Tf) and methanesulfonamide groups, which are key motifs for imparting high stability and specific reactivity in demanding chemical transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and as a sophisticated building block for functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand & Catalyst Synthesis: Acts as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Functional Material Development: Employed in the research of advanced polymers and electronic materials, where its sulfonamide groups can modify material properties.
• Chemical Biology Probe: Utilized in the design of activity-based probes for studying enzyme mechanisms and protein function.
• High-Performance Additive: Investigated for use as a specialty additive in electrolytes or coatings to improve performance characteristics.

Basic Information

Product Name	1,1,1-Trifluoro-n-(4-Nitrophenyl)-n-[(Trifluoromethyl)Sulfonyl]Methanesulfonamide
CAS No.	37595-77-0
Molecular Formula	C9H4F6N2O6S2
Molecular Weight	414.26 g/mol
Synonyms	N-(4-Nitrophenyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide; 1,1,1-Trifluoro-N-(4-nitrophenyl)-N-[(trifluoromethyl)sulfonyl]methanesulfonamide; N-(4-Nitrophenyl)-N-(trifluoromethylsulfonyl)-1,1,1-trifluoromethanesulfonamide; 4-Nitro-N-[(trifluoromethyl)sulfonyl]-N-(trifluoromethylsulfonyl)aniline; Bis(trifluoromethanesulfonyl)-4-nitroaniline; 4-Nitroaniline, N,N-bis(trifluoromethanesulfonyl)-; Tf2N-4-Nitroaniline Derivative
EINECS	Contact for details

Quality Control

Our production of 1,1,1-Trifluoro-n-(4-Nitrophenyl)-n-[(Trifluoromethyl)Sulfonyl]Methanesulfonamide adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.