Description

4-Bromo-2-Butenenitrile is a versatile brominated alkenyl nitrile building block, essential for introducing both a reactive alkene and a nitrile functionality into target molecules. Its value lies in enabling efficient carbon-carbon bond formation and serving as a precursor for heterocyclic synthesis, which is critical for developing advanced materials and active pharmaceutical ingredients. This high-purity intermediate is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for constructing heterocyclic cores and introducing functional handles for further derivatization.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents, where its reactive sites allow for the creation of complex, bioactive molecules.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials with tailored properties.
• Organic Synthesis Building Block: Employed in Michael addition reactions, cycloadditions, and palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to create complex organic compounds.
• Ligand and Catalyst Development: Utilized for synthesizing novel chelating ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a precursor for creating activity-based probes or affinity tags to study biological systems.

Basic Information

Product Name	4-Bromo-2-Butenenitrile
CAS No.	37590-23-1
Molecular Formula	C4H4BrN
Molecular Weight	145.98 g/mol
Synonyms	trans-4-Bromo-2-butenenitrile; (E)-4-Bromo-2-butenenitrile; 4-Bromo-2-butenenitrile; 4-Bromocrotononitrile; 2-Butenenitrile, 4-bromo-; Crotononitrile, 4-bromo-; Bromocrotononitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Butenenitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation via spectroscopic methods, to meet the stringent requirements of research and industrial applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 8°C for extended stability, although the product is stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.