Description

3-Hydroxyacetaminophen is a key pharmaceutical intermediate and metabolite of the widely used analgesic and antipyretic drug, acetaminophen. This compound is of significant importance in the research and development of new therapeutic agents and for conducting detailed metabolic studies. It serves as a critical building block for medicinal chemists and analytical scientists, particularly in the pharmaceutical and life sciences sectors. The high-purity material is essential for ensuring the accuracy and reliability of pharmacokinetic data and impurity profiling.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel analgesic and antipyretic drug candidates and related chemical entities.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for the quantification of acetaminophen metabolites in biological matrices (plasma, urine) during pharmacokinetic and toxicological studies.
• Impurity Standard: Employed in pharmaceutical quality control to identify, quantify, and monitor process-related impurities in acetaminophen Active Pharmaceutical Ingredient (API) and finished dosage forms, ensuring compliance with ICH guidelines.
• Biochemical Research: Utilized in studies investigating the metabolic pathways, mechanisms of action, and potential toxicity profiles of acetaminophen.
• Chemical Synthesis: Acts as a versatile synthon for the preparation of more complex molecules for medicinal chemistry research due to its reactive phenolic and amide functional groups.

Basic Information

Product Name	3-Hydroxyacetaminophen
CAS No.	37519-14-5
Molecular Formula	C8H9NO3
Molecular Weight	167.16 g/mol
Synonyms	3'-Hydroxyacetaminophen; N-(3-Hydroxyphenyl)acetamide; 3-Hydroxyacetanilide; 3-Acetamidophenol; m-Hydroxyacetanilide; APAP-3-ol; Metabolite of Acetaminophen; Paracetamol Metabolite
EINECS	Contact for details

Quality Control

Our 3-Hydroxyacetaminophen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.