Description

n-Acetyl-D-Glucosamine 2-Epimerase is a specialized enzyme that catalyzes the reversible epimerization of N-acetyl-D-glucosamine to N-acetyl-D-mannosamine. This reaction is a critical step in the biosynthetic pathway for sialic acids, which are essential biomolecules involved in cellular recognition and signaling. This high-purity enzyme is indispensable for research and development in the pharmaceutical and biotechnology sectors, particularly for the synthesis of sialylated glycoconjugates, glycoengineering, and the production of advanced therapeutic agents.

Application

• Biocatalysis for Sialic Acid Synthesis: Key catalyst in the enzymatic production of N-acetylneuraminic acid (sialic acid) and its derivatives.
• Glycoprotein & Glycolipid Research: Used in laboratories to study and modify the glycosylation patterns of proteins and lipids.
• Pharmaceutical Intermediate Production: Enables the efficient, stereoselective synthesis of intermediates for antiviral drugs and other sialic acid-based therapeutics.
• Nutraceutical Development: Applied in the research and production of advanced dietary supplements targeting cellular health and immune function.
• Diagnostic Reagent Formulation: A component in enzymatic assay kits for the detection and quantification of specific carbohydrates or related enzymes.
• Enzyme Engineering Studies: Serves as a model enzyme for protein engineering aimed at improving stability, activity, or substrate specificity.

Basic Information

Product Name	n-Acetyl-D-Glucosamine 2-Epimerase
CAS No.	37318-34-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Acetylglucosamine 2-epimerase; UDP-N-Acetylglucosamine 2-Epimerase; GlcNAc 2-Epimerase; N-Acetyl-D-glucosamine 2-epimerase; 2-Epimerase; EC 5.1.3.8; UDP-GlcNAc 2-epimerase; Amino sugar epimerase
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Glucosamine 2-Epimerase is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing to ensure high specific activity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include data on activity (U/mg), protein content, and purity by SDS-PAGE. Our quality commitment aligns with the standards required for research and bioprocessing applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Specific Activity	≥ XX U/mg protein
Protein Content (Bradford)	≥ XX %
Purity (SDS-PAGE)	≥ XX %
Identification (Activity)	Conforms
pH (in solution)	6.5 - 7.5
Endotoxin (LAL)	< 1.0 EU/mg
Biological Activity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.