Description

Scorpion Toxin Ii, Androctonus is a specific, high-purity peptide toxin isolated from the venom of the Androctonus scorpion species. This compound is a critical research tool for studying voltage-gated potassium (Kv) channels, particularly the Kv1.1, Kv1.2, and Kv1.3 subtypes, due to its potent and selective inhibitory activity. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in ion channel research, neurophysiology studies, and the development of novel therapeutic agents targeting neurological disorders and autoimmune diseases.

Application

• Ion Channel Research: A primary tool for blocking and characterizing voltage-gated potassium channels (Kv1.1, Kv1.2, Kv1.3) in electrophysiology experiments.
• Neuroscience & Neuropharmacology: Used to study neuronal excitability, synaptic transmission, and the role of specific Kv channels in disease models.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening for new channel modulators and therapeutic candidates.
• Toxicology & Venom Studies: Employed in comparative venom analysis and to understand the mechanism of action of scorpion envenomation.
• Biomarker & Diagnostic Research: Potential use in developing assays to detect channelopathies or autoimmune conditions linked to Kv channel dysfunction.
• Academic & Institutional Research: Fundamental reagent for university and government lab studies in cellular physiology and molecular biology.

Basic Information

Product Name	Scorpion Toxin Ii, Androctonus
CAS No.	37309-04-9
Molecular Formula	C184H281N55O53S7
Molecular Weight	~4230.8 g/mol
Synonyms	Androctonus australis Hector toxin II; AaH II; Kaliotoxin; KTX; Toxin II from Androctonus australis Hector; Potassium channel toxin α-KTx 3.6; ShK-like peptide; Neurotoxin II
EINECS	Contact for details

Quality Control

Our Scorpion Toxin Ii, Androctonus is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, peptide content, solubility, and biological activity where applicable. Our quality system supports research requiring reliable and well-characterized biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or aqueous buffer
Biological Activity	Verified by functional assay (e.g., channel inhibition)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.