Description

Human Pf-4 CAS NO 37270-94-3 is a high-purity, biologically active platelet factor 4 (PF4) protein, a critical chemokine involved in hemostasis, inflammation, and immune regulation. Its consistent quality and activity are essential for reliable research and diagnostic assay development. This product is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical, and in vitro diagnostic (IVD) industries.

Application

• Biomedical Research: Used as a key reagent in studies of platelet biology, angiogenesis, inflammation, and immune complex diseases.
• Diagnostic Development: Serves as a critical antigen and calibrator in the development and quality control of immunoassays for heparin-induced thrombocytopenia (HIT).
• Drug Discovery & Screening: Employed in target validation and high-throughput screening (HTS) platforms to identify novel therapeutics targeting PF4-related pathways.
• Cell Culture & Signaling Studies: Used to stimulate cellular responses and investigate chemokine receptor (CXCR3) signaling mechanisms in vitro.
• Reference Standard: Acts as a purity and activity reference standard for the qualification of other PF4 preparations and related materials.

Basic Information

Product Name	Human Pf-4
CAS No.	37270-94-3
Molecular Formula	C165H277N51O52S4
Molecular Weight	~7.8 kDa (monomer)
Synonyms	Platelet Factor 4; PF4; CXCL4; Chemokine (C-X-C motif) ligand 4; Oncostatin A; SCYB4; Iroplact; Heparin-binding protein; Thrombocytin; Endothelial Cell Growth Inhibitor
EINECS	Contact for details

Quality Control

Our Human PF-4 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by mass spectrometry, purity assessment by HPLC and SDS-PAGE, and functional activity testing. A detailed Certificate of Analysis (COA) documenting purity, endotoxin levels, and biological activity is provided with every shipment to ensure it meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Purity (SDS-PAGE)	≥ 95%, single band
Biological Activity	Determined by functional assay
Endotoxin	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.