Description

Hyaluronidase CAS NO 37259-53-3 is a purified enzyme that catalyzes the hydrolysis of hyaluronic acid, a key component of the extracellular matrix. This action is critical for increasing tissue permeability and facilitating the diffusion of injected drugs and fluids. It is an essential reagent in pharmaceutical manufacturing, research, and clinical applications where controlled substrate breakdown or enhanced substance dispersion is required.

Application

• Pharmaceutical Adjuvant: Used to enhance the absorption and dispersion of other injected drugs (e.g., local anesthetics, antibiotics, contrast media) by reducing tissue barrier resistance.
• Ophthalmic Surgery: Employed to create a space for surgical procedures by hydrolyzing the vitreous humor and facilitating the administration of intraocular medications.
• Subcutaneous Fluid Administration (Hypodermoclysis): Aids in the rehydration of patients by promoting the spread and absorption of large volumes of subcutaneous fluids.
• Diagnostic Agent Enhancement: Improves the diffusion of radiocontrast agents in subcutaneous urography and other imaging techniques.
• Biochemical Research: Serves as a tool enzyme for studying glycosaminoglycan structure and function, cell migration, and extracellular matrix biology.
• Cosmeceutical & Dermal Formulations: Investigated for use in products designed to improve skin permeability and the delivery of active ingredients.

Basic Information

Product Name	Hyaluronidase
CAS No.	37259-53-3
Molecular Formula	N/A (Protein/Enzyme)
Molecular Weight	~61,000 Da (Approximate, varies by source and isoform)
Synonyms	Hyaluronoglucosaminidase; Hyaluronate 4-glycanohydrolase; Spreading Factor; Alidase; Wydase; Hyazyme; Hyalase; Ronidase; Amphadase; Hylase "Dessau"
EINECS	253-440-6

Quality Control

Our Hyaluronidase is manufactured and tested to meet high-purity standards suitable for research and pharmaceutical applications. Each batch undergoes rigorous analysis to ensure specific activity, purity, and the absence of significant impurities. A comprehensive Certificate of Analysis (COA) detailing assay, protein content, sterility (where applicable), and specific activity is provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, keep the desiccant in the original container and avoid frequent exposure to room temperature.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (IR)	Conforms
Protein Content (Biuret)	> 95%
Specific Activity	> 1500 USP units/mg (or as per grade)
pH (in solution)	6.0 - 7.5
Loss on Drying	< 5.0 %
Bacterial Endotoxins	< 1.0 EU/USP unit (for injectable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.