Description

Hemoglobin Aa is a specific, purified form of hemoglobin, a vital oxygen-transporting metalloprotein found in red blood cells. This high-purity compound is essential for research and development in life sciences, where precise biochemical interactions are studied. It serves as a critical reagent for scientists and manufacturers in the pharmaceutical, diagnostic, and biotechnology sectors, enabling advancements in therapeutic development and clinical testing.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies, oxygen-binding kinetics, and protein interaction assays.
• Diagnostic Reagent Manufacturing: Serves as a key component in the calibration and formulation of in-vitro diagnostic (IVD) kits, particularly for hematology analyzers.
• Pharmaceutical Development: Employed in the research of blood substitutes, hemoglobin-based oxygen carriers (HBOCs), and novel therapeutic agents.
• Reference Standard: Acts as a high-purity calibrant or quality control material in clinical and analytical laboratories.
• Cell Culture & Biotechnology: Utilized in specialized cell culture media and as a protein source in various bioprocessing applications.

Basic Information

Product Name	Hemoglobin Aa
CAS No.	37248-06-9
Molecular Formula	C2952H4664N812O832S8Fe4
Molecular Weight	~64,500 Da (for alpha chain tetramer)
Synonyms	Hemoglobin A (human); HbA; Oxyhemoglobin A; Hemoglobin, adult major component; α-2/β-2 Tetramer; Deoxyhemoglobin A; Methemoglobin A; Hemoglobin subunit alpha/Hemoglobin subunit beta complex
EINECS	Contact for details

Quality Control

Our Hemoglobin Aa is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including purity assay by HPLC, spectral analysis for confirmation of the oxy/deoxy state, and tests for methemoglobin content. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific biological activity is provided to ensure it meets the rigorous standards required for research and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a cool, dry place upon receipt. For extended storage under inert atmosphere, please contact our technical support.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Conforms to standard spectrum
Purity (HPLC)	≥ 95% (HbA)
Methemoglobin Content	≤ 3%
Protein Content (Biuret)	≥ 95% of total
Solubility	Clear solution in buffer
Biological Activity (O2 binding)	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.