Description

Histone CAS NO 37244-51-2 is a complex mixture of basic nuclear proteins that are essential for the structural organization of DNA into chromatin. This product is critical for research and development in epigenetics, gene regulation, and chromatin biology. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in life science studies and drug discovery.

Application

• Epigenetic Research: Fundamental substrate for studying histone modifications (e.g., acetylation, methylation) and their role in gene expression.
• Chromatin Assembly & Remodeling Studies: Used in in vitro assays to reconstitute nucleosomes and investigate chromatin dynamics.
• Biochemical Reagent: Serves as a key component in enzyme activity assays for histone-modifying enzymes like histone deacetylases (HDACs) and methyltransferases (HMTs).
• Diagnostic Development: Potential use as an antigen or standard in the development of assays for detecting autoantibodies or histone-related biomarkers.
• Pharmaceutical Screening: Employed in high-throughput screening platforms to identify novel therapeutics targeting epigenetic pathways.
• Cell Biology: Used in studies of cell cycle, apoptosis, and DNA repair mechanisms where chromatin structure is pivotal.

Basic Information

Product Name	Histone
CAS No.	37244-51-2
Molecular Formula	Mixture
Molecular Weight	Varies by subtype
Synonyms	Histone Proteins; Calf Thymus Histone; Histone Preparation; Core Histones; Linker Histones; H1, H2A, H2B, H3, H4; Nucleohistone; Histone Fraction
EINECS	Contact for details

Quality Control

Our Histone is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and biological activity, meeting the exacting standards required for critical research applications. Certificates of Analysis (COA) detailing specifications such as protein concentration, purity by electrophoresis, and absence of contaminating nucleases are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Electrophoresis)	Characteristic band pattern corresponding to histone subtypes
Protein Content (Biuret)	≥ 90%
Purity (SDS-PAGE)	Major histone bands constitute ≥ 80% of total protein
Solubility	Soluble in water or appropriate buffer
DNase/RNase Activity	Not detected
Biological Activity	Suitable for nucleosome assembly assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.