Description

Bungarotoxin CAS NO 37209-28-2 is a potent neurotoxic polypeptide isolated from the venom of krait snakes (*Bungarus* species). This compound is of significant scientific and commercial value due to its high specificity and affinity for nicotinic acetylcholine receptors (nAChRs). It is an essential research tool for neuroscientists, pharmacologists, and toxicologists studying neuromuscular junctions, receptor function, and neurotoxin mechanisms. Its primary applications are in advanced life science research and pharmaceutical development.

Application

• Neuroscience Research: Irreversible blockade of nicotinic acetylcholine receptors at the neuromuscular junction and neuronal synapses.
• Pharmacological Studies: Used as a selective antagonist to characterize receptor subtypes and study signal transduction pathways.
• Toxicology & Venom Research: A key reference standard for studying snake venom composition and developing antivenoms.
• Drug Discovery: Tool compound for screening and validating potential therapeutics targeting cholinergic systems.
• Cell Biology & Physiology: Employed in patch-clamp experiments and other assays to investigate ion channel function.
• Biochemical Assay Development: Serves as a critical component in developing receptor-binding assays and diagnostic tests.

Basic Information

Product Name	Bungarotoxin
CAS No.	37209-28-2
Molecular Formula	C58H88N18O19S4
Molecular Weight	~1400 g/mol (monoisotopic)
Synonyms	α-Bungarotoxin; Bungarotoxin, α-; BGTX; α-Bgt; Nicotinic Acetylcholine Receptor Antagonist; Toxin, α-Bungaro-; Bungarus multicinctus venom toxin; Long neurotoxin 1; α-Neurotoxin
EINECS	Contact for details

Quality Control

Our Bungarotoxin is produced and tested to meet the stringent requirements of research and development applications. Each batch undergoes comprehensive analysis to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, which includes data from HPLC for purity assessment, mass spectrometry for identity confirmation, and functional bioassays for potency verification. We adhere to a rigorous quality management system to guarantee batch-to-batch consistency and reliable performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity	Fully active; IC50 conforms to batch-specific range
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.