Description

Oxyhemoglobin S CAS NO 37203-69-3 is the oxygenated form of hemoglobin S, the variant protein responsible for sickle cell disease. This compound is of critical importance for biochemical and pharmaceutical research focused on understanding hemoglobinopathies and developing novel therapeutic strategies. It is primarily utilized by research institutions, diagnostic manufacturers, and biopharmaceutical companies engaged in hematology studies, drug discovery for sickle cell disease, and the development of advanced diagnostic assays.

Application

• Biomedical Research: Fundamental studies on the oxygen-binding kinetics, stability, and polymerization behavior of hemoglobin S to understand sickle cell pathophysiology.
• Therapeutic Development: Serving as a key reference standard and target molecule in the screening and evaluation of potential anti-sickling agents and hemoglobin modifiers.
• Diagnostic Manufacturing: Use as a calibrated control or standard in the production of in-vitro diagnostic (IVD) kits for hemoglobin variant analysis and sickle cell screening.
• Spectroscopic Studies: Essential for UV-Vis and other spectroscopic analyses to establish reference spectra and validate analytical methods for hemoglobin characterization.
• Educational & Reference Material: Supplied to academic and clinical laboratories for teaching purposes and as a high-purity biochemical reagent.

Basic Information

Product Name	Oxyhemoglobin S
CAS No.	37203-69-3
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	HbS (Oxy form); Oxy-HbS; Hemoglobin S (Oxygenated); Sickle Cell Hemoglobin (Oxy); Oxy-Hb (β6 Glu→Val); HBB p.Glu6Val (Oxy); Deoxyhemoglobin S (oxygenated form)
EINECS	Contact for details

Quality Control

Every batch of Oxyhemoglobin S is produced and analyzed under stringent conditions to ensure research-grade purity and consistency. Our quality protocol includes verification of spectral purity (A540/A576 ratio), assessment of methemoglobin content, and confirmation of the sickle cell variant via electrophoresis or HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, and spectral characteristics is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use. For short-term use, store at 2-8°C for up to one week.

Specification

Item	Specification
Appearance	Red, clear solution
Identification (UV-Vis)	Characteristic oxyhemoglobin spectrum with peaks at ~415, 540, and 576 nm
Purity (HPLC)	≥ 95% (HbS Oxy form)
Methemoglobin Content	≤ 3%
Protein Concentration	Specified on COA (typically 5-10 mg/mL in buffer)
Solvent/Buffer	Phosphate Buffer or as specified
Sterility (if required)	0.2 µm filtered

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.