Description

7-Hydroxyamoxapine is a key pharmaceutical intermediate and metabolite of the antipsychotic agent amoxapine. This compound is of significant interest in the research and development of neuropharmacological agents and analytical reference standards. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of high-purity reference materials for applications in drug metabolism studies, pharmacokinetic research, and quality control testing.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis and research of novel psychotropic drugs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS, HPLC) for studying the metabolism and pharmacokinetics of amoxapine.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate the pharmacological activity and safety profile of amoxapine derivatives.
• Quality Control: Essential for the identification and quantification of impurities and related substances in amoxapine active pharmaceutical ingredient (API) batches.
• Clinical Toxicology: Used as a calibrant or control in forensic and clinical toxicology laboratories for amoxapine overdose cases.

Basic Information

Product Name	7-Hydroxyamoxapine
CAS No.	37081-76-8
Molecular Formula	C₁₇H₁₆N₃O₂
Molecular Weight	294.33 g/mol
Synonyms	7-Hydroxyamoxapine; 8-Chloro-6-(2-piperazinyl)dibenzo[b,f][1,4]oxazepin-7-ol; 7-Hydroxy-8-chloro-6-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine; Amoxapine metabolite 7-OH; 7-OH-Amoxapine; 7-Hydroxy Amoxapine; 37081-76-8
EINECS	Contact for details

Quality Control

Our 7-Hydroxyamoxapine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.