Description

(6R-Trans)-3-[(Carbamoyloxy)Methyl]-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key pharmaceutical intermediate, specifically a derivative of the cephalosporin class of β-lactam antibiotics. Its primary value lies in its role as a critical building block for the synthesis of advanced active pharmaceutical ingredients (APIs) targeting bacterial infections. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors focused on developing and producing next-generation antibiotic therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production of potent antibacterial agents for clinical use.
• Research & Development: Employed in medicinal chemistry research for developing novel β-lactam structures with improved efficacy and resistance profiles.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing processes for cephalosporin-based drugs.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Item	Details
Product Name	(6R-Trans)-3-[(Carbamoyloxy)Methyl]-8-Oxo-7-(2-Thienylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	37051-05-1
Molecular Formula	C16H15N3O6S2
Molecular Weight	409.43 g/mol
Synonyms	7β-[2-(2-Thienyl)acetamido]-3-[(aminocarbonyl)oxy]methyl]-3-cephem-4-carboxylic Acid; Cefotiam Intermediate; Cefotiam Precursor; 3-Carbamoyloxymethyl-7β-(2-thienylacetamido)ceph-3-em-4-carboxylic Acid; (6R,7R)-3-[(Aminocarbonyl)oxy]methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporin C-3-CH2OCONH2 Derivative; 7-ACA Derivative
EINECS	Contact for details

Quality Control

Our production of this critical pharmaceutical intermediate adheres to stringent GMP (Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical methods including HPLC for purity and impurity profiling, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.