Description

(+)-Diop CAS NO 37002-48-5 is a high-purity chiral ligand and catalyst, specifically the (R,R)-enantiomer of 2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane. This compound is critically valued for its exceptional ability to induce stereoselectivity in asymmetric synthesis, enabling the production of enantiomerically pure intermediates. It is an essential tool for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over molecular chirality.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in the synthesis of enantiomerically pure agrochemicals.
• Key reagent for asymmetric C-C bond formation, including allylic alkylation.
• Used in academic and industrial R&D for developing novel stereoselective synthetic routes.
• Employed in the production of specialty chemicals and advanced materials requiring specific chirality.
• Facilitates the synthesis of chiral building blocks for flavors, fragrances, and bioactive molecules.

Basic Information

Product Name	(+)-Diop
CAS No.	37002-48-5
Molecular Formula	C29H32O2P2
Molecular Weight	474.51 g/mol
Synonyms	(R,R)-(-)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane; (4R,5R)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane; (R,R)-DIOP; (+)-4,5-Bis(diphenylphosphino)-2,2-dimethyl-1,3-dioxolane; (R,R)-1,2-Bis(diphenylphosphino)propane-1,2-diol Acetonide; DIOP, (R,R)-(-)-; (-)-DIOP; (R,R)-(-)-4,5-Bis(diphenylphosphino)-2,2-dimethyl-1,3-dioxolane
EINECS	253-300-2

Quality Control

Our (+)-Diop is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and 31P NMR, to ensure it meets the high standards required for asymmetric catalysis. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	118 - 122 °C
Specific Rotation [α]D20	-18.0° to -22.0° (c=1 in benzene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.