Description

Alprazolam 5,6-Epoxide is a key intermediate and metabolite in the synthesis and pharmacokinetic study of the benzodiazepine class of pharmaceuticals. This compound matters for its critical role in research and development, providing essential insights into drug metabolism, impurity profiling, and the development of analytical reference standards. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) and high-purity reference materials.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Alprazolam and its related substances in quality control testing.
• Metabolite Research: Serves as a critical standard in pharmacokinetic and metabolic pathway studies for the benzodiazepine Alprazolam.
• Impurity Profiling: Essential for the identification, characterization, and control of process-related impurities and degradation products in Alprazolam API manufacturing.
• Analytical Method Development: Employed in the development and validation of chromatographic methods (HPLC, LC-MS) for pharmaceutical analysis.
• Forensic and Clinical Toxicology: Used as an analytical standard in forensic laboratories and clinical settings for the precise detection of benzodiazepine metabolites.
• Academic and Institutional Research: Utilized in universities and research institutes for studies on benzodiazepine chemistry, pharmacology, and analytical science.

Basic Information

Product Name	Alprazolam 5,6-Epoxide
CAS No.	36916-14-0
Molecular Formula	C₁₇H₁₃ClN₄O
Molecular Weight	324.76 g/mol
Synonyms	8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine 5,6-Epoxide; Alprazolam 5,6-Oxide; Alprazolam Epoxide; 5,6-Epoxyalprazolam; α-Hydroxyalprazolam (related); Alprazolam Metabolite; U-38873; UNII-9K7JZ2F8C5
EINECS	Contact for details

Quality Control

Our Alprazolam 5,6-Epoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and reference standards. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identification (IR, NMR), and related substance profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.