Description

3α-Hydroxy-11,20-Dioxo-5β-Pregnan-21-Yl β-D-Glucopyranosiduronic Acid is a high-purity steroid glucuronide conjugate, a critical intermediate and reference standard in advanced pharmaceutical research and development. Its primary value lies in its role as a key metabolite or synthetic precursor for corticoid-related compounds, enabling precise analytical work and process development. This product is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on endocrinology, metabolism studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of related steroid metabolites in bioanalytical methods (LC-MS/MS, HPLC).
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Serves as a critical metabolite standard for investigating the biotransformation pathways of synthetic corticosteroids.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key building block in the multi-step synthesis of specialized corticosteroid APIs.
• Biochemical Research: Employed in enzymatic studies related to glucuronidation processes and steroid hormone regulation.
• Quality Control Testing: Utilized in impurity profiling and method validation for ensuring the purity and safety of steroid-based pharmaceuticals.
• Diagnostic Reagent Development: A potential component in the development of immunoassays or clinical diagnostic kits for hormone level monitoring.

Basic Information

Product Name	3α-Hydroxy-11,20-Dioxo-5β-Pregnan-21-Yl β-D-Glucopyranosiduronic Acid
CAS No.	36707-55-8
Molecular Formula	C27H38O11
Molecular Weight	538.59 g/mol
Synonyms	21-Hydroxy-11,20-dioxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid; Tetrahydrocortisol glucuronide; 3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one 3-glucuronide; 5β-Tetrahydrocortisol 3-glucuronide; THF-3G; Urocortisol glucuronide; Steroid glucuronide conjugate; 3α-Hydroxy-11,20-dioxopregnan-21-yl glucuronide
EINECS	Contact for details

Quality Control

Our 3α-Hydroxy-11,20-Dioxo-5β-Pregnan-21-Yl β-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.