Description

Glucagon (1-21) is a synthetic peptide fragment of the glucagon hormone, identified by CAS NO 36489-11-9. This high-purity peptide is critical for pharmaceutical research and development, particularly in metabolic studies and therapeutic applications. It serves as a vital reference standard and active pharmaceutical ingredient (API) intermediate for researchers and manufacturers in the biopharmaceutical and life sciences sectors.

Application

• Pharmaceutical Research: Used as a reference standard and key intermediate in the development of glucagon-based therapeutics.
• Metabolic Disorder Studies: Essential for in-vitro and in-vivo research on diabetes, hypoglycemia, and other metabolic pathways.
• Biochemical Assay Development: Serves as a critical component in the development and validation of diagnostic assays and screening tests.
• Peptide Chemistry & Synthesis: Acts as a building block or precursor for the synthesis of longer peptide chains and analogs.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental endocrinology and peptide hormone research.
• Quality Control: Employed as a system suitability standard in analytical laboratories for method development and purity assessment.

Basic Information

Product Name	Glucagon (1-21)
CAS No.	36489-11-9
Molecular Formula	C₁₄₈H₂₂₈N₄₂O₄₉S
Molecular Weight	3353.8 g/mol
Synonyms	Glucagon Fragment 1-21; HGTV-28; Glucagon (1-21), human; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-OH; Glucagon 1-21 amide (common misnomer); Glucagon N-terminal fragment
EINECS	Contact for details

Quality Control

Our Glucagon (1-21) is manufactured under strict quality systems to ensure the highest standards of purity and consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and specifications can be tailored to meet specific pharmacopeial requirements (e.g., USP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This hygroscopic (moisture-sensitive) material should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% on anhydrous basis
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.