Description

D-Alanine, 3-Fluoro-n-[(Phenylmethoxy)Carbonyl]- is a specialized, non-natural amino acid derivative featuring a fluorine atom and a Cbz-protecting group. This compound is a crucial chiral building block in advanced organic synthesis, enabling the introduction of fluorine and specific stereochemistry into target molecules. It is primarily utilized by pharmaceutical research and development teams for the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated peptide-based drugs and protease inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the effects of fluorination on bioactivity, metabolic stability, and membrane permeability.
• Peptide Synthesis: Serves as a protected fluorinated D-alanine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate enzyme specificity and mechanism.
• Chemical Biology: Useful for incorporating stable, non-radioactive fluorine labels into peptides for various biophysical and analytical studies.
• Agrochemical Research: Potential intermediate in the design of novel fluorinated bioactive compounds with pesticidal or herbicidal activity.

Basic Information

Product Name	D-Alanine, 3-Fluoro-n-[(Phenylmethoxy)Carbonyl]-
CAS No.	36369-37-6
Molecular Formula	C11H12FNO4
Molecular Weight	241.22 g/mol
Synonyms	(R)-2-((Benzyloxy)carbonylamino)-3-fluoropropanoic acid; N-Cbz-3-fluoro-D-alanine; N-[(Benzyloxy)carbonyl]-3-fluoro-D-alanine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-fluoropropanoic acid; Z-3-fluoro-D-Ala-OH; 3-Fluoro-N-carbobenzoxy-D-alanine; N-Carbobenzyloxy-3-fluoro-D-alanine; 3-Fluoro-D-alanine N-benzyloxycarbonyl derivative
EINECS	Contact for details

Quality Control

Our D-Alanine, 3-Fluoro-n-[(Phenylmethoxy)Carbonyl]- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.