Description

(R)-n-Cbz-2-Amino-3-Fluoropropanoic Acid CAS NO 36369-34-3 is a high-purity, non-natural amino acid derivative featuring a chiral center and a fluorine atom, making it a critical building block for advanced pharmaceutical research and development. Its primary value lies in enabling the synthesis of novel peptide-based therapeutics with enhanced metabolic stability, bioavailability, and targeted biological activity. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical R&D, particularly for the creation of protease inhibitors, peptide hormones, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially fluorinated peptides and peptidomimetics.
• Protease Inhibitor Development: Used in the research and production of inhibitors for diseases where proteases play a key role.
• Peptide-Based Drug Discovery: Incorporation into peptide sequences to improve stability against enzymatic degradation and modulate pharmacokinetic properties.
• Chemical Biology & Probe Synthesis: Serves as a building block for creating fluorescent or affinity-labeled probes to study biological pathways.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for candidate drugs.
• Academic Research: Used in universities and research institutes for studies in asymmetric synthesis, fluorine chemistry, and medicinal chemistry.

Basic Information

Product Name	(R)-n-Cbz-2-Amino-3-Fluoropropanoic Acid
CAS No.	36369-34-3
Molecular Formula	C11H12FNO4
Molecular Weight	241.22 g/mol
Synonyms	(R)-2-(((Benzyloxy)carbonyl)amino)-3-fluoropropanoic Acid; (R)-N-Carbobenzoxy-3-fluoroalanine; (R)-N-Cbz-3-fluoroalanine; (R)-3-Fluoro-N-Cbz-alanine; (2R)-2-{[(Benzyloxy)carbonyl]amino}-3-fluoropropanoic Acid; Fmoc-3-F-D-Ala-OH (related protected form); Z-3-F-D-Ala-OH
EINECS	Contact for details

Quality Control

Our (R)-n-Cbz-2-Amino-3-Fluoropropanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, ensuring reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.