Description

H-Ala-Pro-Gly-Oh CAS NO 36301-96-9 is a synthetic tripeptide derivative, specifically an alanyl-prolyl-glycine derivative, serving as a crucial building block in advanced biochemical research and pharmaceutical development. Its defined sequence makes it an essential intermediate for constructing more complex peptide structures and studying protease specificity. This high-purity compound is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, drug discovery, and biochemical assay development.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the solid-phase and solution-phase synthesis of novel therapeutic peptides.
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies, particularly for investigating proline-specific proteases like dipeptidyl peptidase IV (DPP-IV).
• Drug Discovery: Acts as a core structural motif for developing enzyme inhibitors and modulating peptide-based drug candidates.
• Cosmetic Peptide Synthesis: Employed in the research and development of bioactive peptides for cosmetic applications targeting skin conditioning.
• Academic Research: Provides a well-defined model compound for studying peptide conformation, stability, and intermolecular interactions.

Basic Information

Product Name	H-Ala-Pro-Gly-Oh
CAS No.	36301-96-9
Molecular Formula	C10H17N3O4
Molecular Weight	243.26 g/mol
Synonyms	Alanyl-prolyl-glycine; APG; H-Ala-Pro-Gly-OH; L-Alanyl-L-prolylglycine; Ala-Pro-Gly; Tripeptide APG; 2-[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidin-2-yl]acetic acid; N-(N-L-Alanyl-L-prolyl)glycine
EINECS	Contact for details

Quality Control

Our H-Ala-Pro-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via mass spectrometry (MS) and infrared spectroscopy (IR). We provide Certificates of Analysis (COA) with detailed results, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For extended storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% (by HPLC)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.