Description

5,5-Difluoro-1,3-Dioxane is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the gem-difluoro moiety adjacent to the acetal functionality, enabling precise molecular modifications. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the difluoromethylene ether (CF2-O) group into bioactive molecules, potentially enhancing metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where fluorination is employed to optimize activity and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty fluorinated polymers with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the construction of novel chelating ligands or organocatalysts that leverage the electronic influence of fluorine atoms.
• Fluorine Chemistry Research: A valuable reagent for studying the synthesis and reactivity of fluorinated heterocycles and acetals in academic and industrial R&D settings.

Basic Information

Product Name	5,5-Difluoro-1,3-Dioxane
CAS No.	36301-44-7
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	5,5-Difluoro-1,3-dioxacyclohexane; 5,5-Difluoro-m-dioxane; 1,3-Dioxane, 5,5-difluoro-; Difluoromethylene acetaldehyde dimer (related structure); 2,2-Difluoro-1,3-dioxane
EINECS	Contact for details

Quality Control

Our 5,5-Difluoro-1,3-Dioxane is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing specifications such as assay (by GC or HPLC), identity (by IR/NMR), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. The compound may be moisture-sensitive; keep container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.