Description

Tosyl-L-Asparagine is a protected derivative of the amino acid L-asparagine, where the amine group is shielded by a tosyl (p-toluenesulfonyl) group. This modification is critical for peptide synthesis, preventing unwanted side reactions and enabling precise, sequential chain elongation. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptides, APIs, and biochemical tools. Its high purity and defined stereochemistry ensure reliable and reproducible synthetic outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of complex peptide sequences in both research and GMP manufacturing.
• Pharmaceutical Intermediate: Used in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Biochemical Research: Serves as a crucial reagent for studying enzyme-substrate interactions, protein folding, and metabolic pathways involving asparagine.
• Libraries & Combinatorial Chemistry: Employed to create diverse peptide libraries for drug discovery, screening, and structure-activity relationship (SAR) studies.
• Proteomics & Labeling: Can be utilized in the preparation of modified peptides or as a precursor for introducing specific tags or probes.

Basic Information

Product Name	Tosyl-L-Asparagine
CAS No.	36212-66-5
Molecular Formula	C11H14N2O5S
Molecular Weight	286.30 g/mol
Synonyms	Nα-Tosyl-L-asparagine; L-Asparagine, N-[(4-methylphenyl)sulfonyl]-; N-Tosyl-L-asparagine; (2S)-2-[(4-Methylphenyl)sulfonyl]amino]-3-carbamoylpropanoic acid; p-Toluenesulfonyl-L-asparagine; Tosyl-Asparagine-OH; N-α-Tosyl-L-asparagine; TOS-ASN-OH
EINECS	Contact for details

Quality Control

Our Tosyl-L-Asparagine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical intermediates and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.